Bone Morphogenetic Protein in Pocatello, ID
The active ingredient in INFUSE Bone Graft rhBMP-2 is a manufactured version of a protein already present in the body that promotes new bone growth.
Certain bone morphogenetic proteins, or BMPs, have been studied for decades because of their remarkable ability to heal bone and eliminate the need for bone graft harvesting from other parts of the body. Approximately 20 BMPs have been discovered, but only six appear capable of initiating bone growth. Of these, rhBMP-2 has been studied more than any other BMP and is FDA approved for use in certain spinal, tibial (leg) and oral surgeries.
Naturally occurring BMP is found within the bone itself, but only in small amounts. To provide clinically useful and reproducible amounts of isolated, human BMP, it must be manufactured in a special facility.
Scientists isolated the gene for one protein (BMP-2) from bone tissue and used well-established molecular biology techniques to create genetically engineered cells. These cells then produce large quantities of rhBMP-2. A similar process is used to manufacture other proteins, such as insulin. The recombinant form of rhBMP-2 is identical to the natural form in both its chemistry and its ability to grow new bone.
During surgery, rhBMP-2 is soaked onto and binds with an absorbable collagen sponge (ACS) that is designed to resorb, or disappear, over time. As the sponge dissolves, the rhBMP-2 stimulates the cells to produce new bone. The rhBMP-2 also goes away once it has completed its task of initiating the normal bone healing process.
rhBMP-2 may be used to promote bone growth in several areas of the body. In the spine, the rhBMP-2 grows bone in the disc space to join or fuse the vertebrae to reduce back pain and stabilize the spine. In certain tibial fractures, rhBMP-2 has been shown to help heal broken bones. In instances of jaw bone resorption, rhBMP-2 may be placed in the section or sections of the jaw bone that need to be built back up in preparation for dental implants.
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